ABSTRACT
Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors,serving to supply nutrients and oxygen,and remove metabolic wastes.Kaposi's sarcoma (KS),a multifocal angioproliferative disorder characterized by spindle cell proliferation,neo-angiogenesis,inflammation,and edema,is associated with infection by Kaposi's sarcoma-associated herpesvirus (KSHV).Recent studies indicate that KSHV infection directly promotes angiogenesis and inflammation through an autocrine and paracrine mechanism by inducing pro-angiogenic and pro-inflammatory cytokines.Many of these cytokines are also expressed in KS lesions,implicating a direct role of KSI-IV in the pathogenesis of this malignancy.Several KSHV genes are involved in KSHV-induced angiogenesis.These studies have provided insights into the pathogenesis of KS,and identified potential therapeutic targets for this malignancy.
ABSTRACT
Objective To introduce a new kind of circuit with temperature and voltage double compensation function in view of the deficiency of ambient temperature change on existing respiratory signal detection circuit. Methods The respiratory signal is detected by the characteristics of diode junction voltage with temperature changes. Results The functions of automatic temperatures compensation and automatic voltage fluctuation compensation are realized with the differential connection of two identical diodes. Conclusion The experimental results shows that the proposed circuit is basically immune to the fluctuation of ambient temperature changes and voltage fluctuation, its structure is simple and the accuracy of breathing signal detection is also improved.